Therapeutic targeting of cancer cell metabolism
نویسندگان
چکیده
منابع مشابه
Back to the Future: Therapeutic Targeting of Cancer Cell Metabolism.
An introduction by Raymond Gilmour (Discovery Oncology Research, Lilly Research Laboratories, USA) and Susana Velasco (Cell Signaling Therapies, Centro Nacional de Investigaciones Oncológicas (CNIO), Spain) notes that with new tools and technologies in place, cancer metabolism has become an area of renewed focus for both basic research and drug discovery efforts. The ability to link genetics wi...
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Background: Both mitochondrial dysfunction and aerobic glycolysis are signs of growing aggressive cancer. If altered metabolism of cancer cell is intended, using the glycolysis inhibitor (2-deoxyglucose (2DG)) would be a viable therapeutic method. The AMP-activated protein kinase (AMPK), as a metabolic sensor, could be activated with metformin and it can also launch a p53-dependent metabolic ch...
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Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second leading cause of cancer death by 2030. Current therapeutic options are limited, warranting an urgent need to explore innovative treatment strategies. Due to specific microenvironment constraints including an extensive desmoplastic stroma reaction, PDAC faces major metabolic challenges, principally hypoxia and nutrient depr...
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The metabolic response in mammalian cells requires a coordination of cellular activities that include cell proliferation with nutrient availability, regulation of energy homeostasis and hormonal and stress signaling. Cancer cells require unrestricted energy generation from ATP for their uncontrolled proliferation. Over the last few decades, there are accumulating evidences about the metabolic r...
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ژورنال
عنوان ژورنال: Journal of Molecular Medicine
سال: 2011
ISSN: 0946-2716,1432-1440
DOI: 10.1007/s00109-011-0730-x